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This antibiotic regimen can be offered in case of confirmed maternal infection (documented seroconversion) from 14 weeks and especially in third trimester infections after 32 weeks due to a high risk of fetal infection (60-70%) with no risk of neurological impairment but with risk of ocular disease. This document discusses various perinatal and congenital infections including TORCH infections. It provides details on the causative organisms, modes of transmission, clinical features, diagnosis, and management of toxoplasmosis, rubella, CMV, herpes, HIV, hepatitis B, tuberculosis, varicella zoster virus, syphilis, malaria, and parvovirus infections. Timely diagnosis and treatment of perinatally acquired infections is important. Prevention strategies include maternal screening, vaccination ... INTRODUCTION: TORCH stands for a group of infections that can cause serious congenital defects or severe foetal conditions when acquired during pregnancy, especially before 20 weeks. TORCH includes: (T) toxoplasmosis, (O) other agents, the most common being chickenpox, syphilis, parvovirus B19 and, recently zika virus (R) rubella, (C) cytomegalovirus, (H) herpes simplex virus. Although many of these infections produce similar foetal abnormalities and can present with similar ultrasound ... The term TORCH complex or TORCHes infection refers to the congenital infections of toxoplasmosis, others (Syphilis, Hepatitis B), rubella, Cytomegalovirus (CMV), and herpes simplex.