Senescence: Definition

SENESCENCE definition: 1. the fact of becoming older, and therefore being in less good condition and less able to function…. Learn more. Senescence is the process by which cells stop dividing and enter a state of permanent growth arrest without undergoing cell death. Senescence cells get old and weaken, causing a decline in tissue function and decay. Senescence in plants is a programmed death of leaves as part of developmental cycles. In animals, senescent cells contribute to aging and age-related diseases. Senescence can be induced by unrepaired DNA damage or other cellular stresses. It plays a role in normal development ... Senescence articles from across Nature Portfolio Senescence is the process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing cell death ... In this review, we focus on senescence-associated pathways and therapeutics understanding cellular senescence as a cascade that leads to aging, while discussing the recent details on the molecular pathways involved in regulating senescence and the benefits of therapeutic strategies against accumulated senescent cells and their secretions.