Understand penile cancer with this detailed guide on symptoms, causes, risk factors, diagnosis, and treatment. Learn how early detection improves outcomes. Penile cancer usually forms on or under the foreskin. Human papillomavirus (HPV) causes about one-third of penile cancer cases. When found early, penile cancer is usually curable. Start here to find information on penile cancer treatment and research. Penile cancer affects the penis . Explore penile cancer symptoms, causes, diagnosis methods, and treatment options including surgery, radiation, and chemo. Penile Cancer : Symptoms and Treatments Penile cancer , though relatively rare, is a serious condition that requires early detection and prompt treatment. This malignancy originates in the tissues of the penis and can manifest in several forms, each varying in severity and treatment options.