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Discover the latest breakthroughs in migraine treatment for 2025, including CGRP inhibitors, AI-powered personalized plans, wearable neuroregulators, and mRNA-based therapies. Learn expert ... Most people who have migraines find that their headaches get better with the preventive treatment and lifestyle changes. Though there is no definitive cure for migraine, treatment can successfully lower the frequency and severity of attacks and also help relieve symptoms. There's a wide range of migraine treatment options including prescription drugs, over-the-counter painkillers, devices, natural remedies, and more. Migraine headaches can be treated with two drug approaches: abortive and preventive. Learn more from WebMD about how each type works to curb or shorten migraines.