MALIGNANT meaning : 1. A malignant disease or growth is cancer or is related to cancer, and is likely to be harmful…. Learn more. 4 meanings: 1. having or showing desire to harm others 2. tending to cause great harm; injurious 3. pathology (of a tumour).... Click for more definitions. Learn about the term malignant , which is used to describe a cancerous tumor or serious medical conditions, and how it differs from benign tumors.