Warning signs and symptoms of kidney disease If your kidney function continues to decline, you may start developing symptoms of kidney disease . Each person is different, but most people will start to develop uremia as the kidneys fail and are unable to remove wastes from the body. Kidney disease is often called a silent killer because its symptoms can be mild or go unnoticed until the condition becomes serious. That’s why it’s crucial to recognize the early symptoms of kidney disease and seek medical help in time. If you experience swelling, fatigue, changes in urination, or pain in your kidney area, don’t wait. Information about kidney disease Take control of your kidney health 10 signs you may have kidney disease In its early stages, chronic kidney disease (CKD) is ‘silent’ and doesn’t usually cause symptoms , but as it gets more advanced, there are some signs you may notice.