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Hydroxychloroquine, sold under the brand name Plaquenil among others, is a medication used to prevent and treat malaria in areas where malaria remains sensitive to chloroquine. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth, often in the form of hydroxychloroquine sulfate. [3] Common side effects may include vomiting, headache, blurred vision, and muscle weakness. [3] Severe side effects may include allergic reactions ... Plaquenil is used to treat or prevent malaria and to treat the symptoms of rheumatoid arthritis. Learn about side effects, interactions and indications. Hydrxochloroquine, which is used to treat malaria and other conditions , can cause side effects. Learn about its more common, mild, and serious side effects and how to manage them. Learn about the side effects of Plaquenil (hydroxychloroquine), from common to rare, for consumers and healthcare professionals.