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Epidermoid cysts are non-neoplastic inclusion cysts derived from ectoderm that are lined solely by squamous epithelium. These are discussed separately by anatomic location: epidermal inclusion cyst intracranial epidermoid cyst intradiploic epid... An epidermoid cyst is the most common type of skin cyst . Learn about what they look like and when you should get them removed. What is an epidermoid cyst ? An epidermoid cyst is a benign cyst derived from the infundibulum or upper portion of a hair follicle, encapsulated in a thin layer of epidermis -like epithelium. Epidermoid cysts are typically filled with keratin and lipid -rich debris [1,2]. Synonyms for an epidermoid cyst include: Epidermal cyst Epidermal ... An epidermoid cyst is a harmless growth that contains keratin. Learn more about its symptoms, and treatment options, here.