Learn how cotton and cotton blends differ in texture, durability, breathability, maintenance, cost, and applications. Find out which is better for bedsheets, clothing, and other home textiles. Understanding What is Cotton Blend Fabric Cotton blend fabrics are a harmonious union of natural cotton fibers and synthetic or man-made fibers, such as polyester, rayon, or spandex. This strategic blend combines the best qualities of both fiber types, resulting in a fabric that is soft, breathable, and durable. The upward sloping popularity of cotton blend fabrics is not a secret anymore. The demand for mixed cotton is becoming almost the same as pure cotton . Cotton blend fabric is a versatile material that is made by combining cotton with other fibers such as polyester, rayon, or spandex. This blend offers several advantages over pure cotton fabric.