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Cephalohematoma is a hemorrhage of blood between the skull and the periosteum, often caused by prolonged or instrumental delivery. It can cause swelling, jaundice, anemia or infection, and usually resolves spontaneously within weeks or months. A cephalohematoma is an accumulation of subperiosteal blood, typically located in the occipital or parietal region of the calvarium (see Image. Cephalohematoma). During the birthing process, shearing forces on the skull and scalp result in the separation of the periosteum from the underlying … Point of Care - Clinical decision support for Cephalohematoma. Treatment and management. Introduction, Etiology, Epidemiology, Pathophysiology, History and Physical, Evaluation, Treatment / Management, Differential Diagnosis, Prognosis, Complications, Deterrence and Patient Education, Pearls and Other Issues, Enhancing Healthcare Team Outcomes Cephalohematoma is a birth injury that causes a blood pool under the scalp, but not in the brain. It usually heals on its own, but may need monitoring or drainage in some cases.