Calcium Channel Blockers for High Blood Pressure: Calcium channel blockers are drugs used to lower blood pressure. Learn more about how they work and about their side effects. Overview on calcium channel blockers , in this first part we will discuss their classification, mechanism of action as well as clinical indications. Side Effects of Calcium Channel Blockers While generally well tolerated, calcium channel blockers can cause side effects, which vary depending on the drug class and individual patient factors. Common Side Effects Dihydropyridines: Flushing, headache, dizziness, peripheral edema (ankle swelling), and reflex tachycardia due to vasodilation.
