Pharmaceutical Bioavailability and Bioequivalence Learn about Bioavailability, Bioequivalents, Therapeutic equivalents, In vitro Dissolution, Suprabioavailability, Therapeutic Equivalents, Technical Aspects and Acceptance ranges. Bioavailability refers to the extent and rate at which the active moiety (drug or metabolite) enters systemic circulation, thereby accessing the site of action. Bioavailability of a drug is largely determined by the properties of the dosage form, which depend partly on its design and manufacture. Differences in bioavailability among formulations of a given drug can have clinical significance; thus, knowing whether drug formulations are equivalent is essential. Chemical equivalence indicates ... DEFINITION Bioavailability is defined as the rate and the absorption of drug that reaches the biological system in an active form, capable of exerting the desired pharmacological effect, including its onset, intensity and duration of its action. Abstract Bioavailability, the degree and rate at which a substance is absorbed into the bloodstream and becomes available to its target site of action, is a critical factor in the efectiveness of medications and the utilization of nutrients. This article provides an overview of bioavailability, exploring the factors that influence it, including the route of administration, chemical characteristics of the substance, and individual variations in metabolism. The route of administration plays a ...
