Discover the meaning of ' adversity ,' its historical roots, and how it influences human life. Explore synonyms, antonyms, related terms, and notable quotations. Adversity is a state of hardship or affliction; misfortune; calamity. Learn the origin, synonyms, and usage of the word adversity , and see related expressions and proverbs. Adversity definition: adverse or unfavorable fortune or fate; a condition marked by misfortune, calamity, or distress.. See examples of ADVERSITY used in a sentence. When circumstances or situations work against you, you face adversity . Refugees from war-torn countries encounter terrible adversity .