Adapalene is the only FDA-approved topical retinoid available over-the-counter. Find out if Adapalene is the right acne treatment for you. Adapalene is a retinoid-like compound used to treat acne in adults and children 12 years and older. Learn how to apply it, what precautions to follow, and what side effects to watch out for. Adapalene is used in the treatment of Acne. View Adapalene ’s uses, side-effects, drug interactions, expert advice and user FAQs only on 1mg.com. Adapalene is a topical retinoid that treats acne and other skin conditions by modulating cell growth and reducing inflammation. Learn how to use it, what side effects to expect, and what interactions to avoid with this guide from Apollo Hospitals.