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Isotretinoin can affect your eyesight, hair, muscles, or joints While taking isotretinoin, you may temporarily develop: Trouble seeing at night Thinning hair Muscle (or joint) pain When you stop taking isotretinoin, these side effects tend to go away. Serious side effects of isotretinoin While the above possible side effects are manageable and tend to go away, some side effects are more serious. Dermatologists will tell you about the following possible side effects: Birth defects and other ... Isotretinoin ( Accutane ) is a retinoid medication that treats severe acne. Learn about its warnings, side effects, interactions, and how to use it safely. Accutane is used to treat a type of severe acne (nodular acne) that has not been helped by other treatments, including antibiotics. Because Accutane can cause birth defects, Accutane is only for patients who can understand and agree to carry out all of the instructions in the iPLEDGE REMS. Accutane may cause serious mental health problems. Isotretinoin, also known as Accutane , is a retinoid that treats severe cystic acne, ichthyosis and some cancers. It has many side effects, including birth defects, liver failure and psychiatric problems, and requires strict controls and monitoring.