A mole is a fundamental unit in chemistry. Learn how to convert between moles and grams and why moles are essential in chemical calculations. Mole, standard unit (6.02214076 x 10^23) in chemistry for measuring large quantities of very small entities such as atoms, molecules, or other specified particles. Learn what a mole is and how to calculate the number of moles, molar mass, and related quantities of a substance. A mole is the amount of a substance that contains exactly 6.02214076 " 1023 elementary entities. A mole is a unit of quantity that describes the number of particles in a system. Learn how to use the mole to calculate mass, number of molecules, and molar mass with examples and references.