AIDS , transmissible disease of the immune system caused by the human immunodeficiency virus (HIV). HIV is a lentivirus (literally meaning “slow virus”; a member of the retrovirus family) that slowly attacks and destroys the immune system, the body’s defense against infection, leaving an individual vulnerable to a variety of other infections and certain malignancies that eventually cause death. AIDS is the final stage of HIV infection, during which time fatal infections and cancers ... HIV stands for human immunodeficiency virus. HIV is a retrovirus that infects cells of the human immune system (mainly CD4-positive T-cells and macrophages—key components of the cellular immune system) and destroys or impairs their function. Infection with this virus results in the progressive ... Overview Acquired immunodeficiency syndrome ( AIDS ), is an ongoing, also called chronic, condition. It's caused by the human immunodeficiency virus, also called HIV. HIV damages the immune system so that the body is less able to fight infection and disease. If HIV isn't treated, it can take years before it weakens the immune system enough to become AIDS . Thanks to treatment, most people in the U.S. don't get AIDS . HIV & AIDS Human immunodeficiency virus (HIV) is the virus that causes acquired immune deficiency syndrome ( AIDS ). HIV weakens your immune system by destroying your T-cells until you are unable to fight off even minor illnesses. You can have HIV without any symptoms. Getting tested and starting treatment early gives you the best chance of living a long life.