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The urea cycle is a crucial metabolic pathway responsible for eliminating excess nitrogen from the body. First Reaction: Entering the Urea Cycle . Second Reaction - Urea Cycle in Mitochondria. Urea is formed, enters the bloodstream, is filtered by the kidneys, and is eventually excreted in the urine. The biochemical part of excretion is urea synthesis using the urea cycle , also known as the Ornithine Cycle. It is also known as the Kreb-Henseleit cycle and occurs in the liver. The urea cycle is one of the body’s most vital biochemical mechanisms, ensuring the safe removal of toxic ammonia generated during protein metabolism. Understanding urea cycle biochemistry helps explain how our bodies handle nitrogen waste while maintaining internal balance. This essential pathway transforms harmful ammonia into urea , a much safer compound that is easily excreted through urine. The cycle mainly takes place in the liver, which serves as the primary detoxification organ. In ... What is the urea cycle . Where does it occur. What is the function of the pathway. Learn the pathway with steps, regulations, and a diagram.