SPERM definition: 1. a sex cell produced by a man or male animal: 2. informal for semen (= the liquid produced by…. Learn more. What is Sperm Cell? Sperm cells, scientifically referred to as spermatozoa, serve as the male gametes in sexual reproduction. These specialized cells originate from the male reproductive organs and play a crucial role in fertilization, as they unite with female egg cells to create a diploid zygote, initiating the development of a new organism. Sperm are male sex cells that fertilize female eggs to start pregnancy. Learn about sperm production, structure, health and problems that affect fertility. The meaning of SPERM is semen. How to use sperm in a sentence.