Spinal muscular atrophy ( SMA ) is a lower motor neuron disease with autosomal recessive inheritance. The first cases of SMA were reported by Werdnig in 1891. Although the phenotypic variation of SMA led to controversy regarding the clinical entity of ... Spinal muscular atrophy is a genetic disorder affecting motor neurons, causing muscle weakness and atrophy. Learn about its symptoms, diagnosis, and management. Spinal muscular atrophy ( SMA ) causes muscle weakness and progressive loss of movement. It is caused by deterioration in the nerve cells (motor neurons) connecting the brain and spinal cord to the body’s muscles.
