Dive into the definition of protagonist , explore their key traits, and learn how to create a captivating lead character for your next story. PROTAGONIST definition : 1. one of the main characters in a story or a play 2. an important supporter of an idea or…. Learn more. Protagonist definition : the leading character, hero, or heroine of a drama or other literary work.. See examples of PROTAGONIST used in a sentence. The meaning of PROTAGONIST is the principal character in a literary work (such as a drama or story). How to use protagonist in a sentence. Did you know?