Prochlorperazine is used to treat nervous, emotional, and mental conditions (eg, schizophrenia) and non-psychotic anxiety. It is also used to control severe nausea and vomiting. This medicine should not be used to treat behavioral problems in older adult patients who have dementia. This medicine is available only with your doctor's prescription. Discover how Prochlorperazine works, its uses for nausea, vertigo, and migraines, dosage guidelines, side effects, and alternatives. Learn more about this antiemetic today. Prochlorperazine is a first-generation antipsychotic. FDA indications include schizophrenia, schizoaffective, and other conditions presenting with symptoms of psychosis, as well as nausea and vomiting (post-chemotherapy, post-radiation therapy, pre- and post-operative setting, and other conditions). Non-FDA Indications include migraine headaches. This activity outlines the indications, mechanism of action, methods of administration, significant adverse effects, contraindications, monitoring ...