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Povidone- Iodine Topical Dosage Forms Povidone iodine is a topical medication that decreases your risk of developing a skin or eye infection. Follow the instructions on the label to safely use this product as directed. Povidone-iodine is a topical antiseptic agent used for the treatment and prevention of infection in wounds. Povidone- Iodine is an iodophor solution containing a water-soluble complex of iodine and polyvinylpyrrolidone (PVP) with broad microbicidal activity. Free iodine , slowly liberated from the polyvinylpyrrolidone iodine (PVPI) complex in solution, kills eukaryotic or prokaryotic cells through iodination of lipids and oxidation of cytoplasmic and membrane compounds. This agent exhibits a broad range of microbicidal activity against bacteria, fungi, protozoa, and viruses. Slow release of iodine ... Povidone Iodine is an over-the-counter medication used as a topical antiseptic and for surgical scrub.