Pemphigus has three major variants, which are classified depending on the basis of the clini-cal, histological features, immunofluorescence staining patern and autoantibody profile of the disease including pemphigus vulgaris (PV), pemphigus foliaceus (PF), and paraneoplastic pemphigus (PNP), which all have further subtypes. Pemphigus is a group of autoimmune skin conditions that cause blisters and sores on your skin and mucous membranes. Learn about the different types, symptoms, causes and treatment options for pemphigus. What is Pemphigus Vulgaris? Pemphigus Vulgaris is an autoimmune disease that primarily affects the skin and mucous membranes. In this condition, the body's immune system mistakenly attacks proteins in the skin called desmogleins, which are essential for holding skin cells together. This leads to the formation of blisters and erosions, causing significant discomfort and increasing the risk of infections. Pemphigus vulgaris is the most common type worldwide, but as noted above, pemphigus foliaceus is more common in some places, such as certain rural regions of Brazil and Tunisia.
