Manipulate definition : to manage or influence skillfully, especially in an unfair manner.. See examples of MANIPULATE used in a sentence. Learn the meaning of manipulate as a verb, with different senses and examples. Find synonyms, pronunciation, grammar, and related words for manipulate . MANIPULATING definition : 1. present participle of manipulate 2. to control something or someone to your advantage, often…. Learn more. Define manipulate . manipulate synonyms, manipulate pronunciation, manipulate translation, English dictionary definition of manipulate . tr.v. ma·nip·u·lat·ed , ma·nip·u·lat·ing , ma·nip·u·lates 1. To move, arrange, operate, or control by the hands or another body part or by mechanical means,...