2 meanings: 1. any structural change in a bodily part resulting from injury or disease 2. an injury or wound.... Click for more definitions. A lesion is a mark on the skin that looks or feels different than the surrounding skin. Everything from a blister to a bug bite could be referred to as a lesion. Lesion definition: an injury; hurt; wound.. See examples of LESION used in a sentence. The meaning of LESION is injury, harm. How to use lesion in a sentence.
