Point of Care - Clinical decision support for Lamotrigine . Treatment and management. Indications, Mechanism of Action, Administration, Adverse Effects, Contraindications, Monitoring, Toxicity, Enhancing Healthcare Team Outcomes Lamotrigine is used alone or with other medications to prevent or control seizures (epilepsy).Learn about side effects, dosages, drug interactions, and more. Lamotrigine likely acts by inhibiting sodium currents by selective binding to the inactive sodium channel, suppressing the release of the excitatory amino acid, glutamate. The mechanism of action of lamotrigine in reducing anticonvulsant activity is likely the same in managing bipolar disorder. 5. Patients prescribed lamotrigine tablets have sometimes been given the wrong medicine because many medicines have names similar to lamotrigine tablets, so always check that you receive lamotrigine tablets. Taking the wrong medication can cause serious health problems. When your healthcare provider gives you a prescription for lamotrigine tablets: