Itraconazole is a medication used in the management and treatment of fungal infections. It is in the antifungal class of drugs. Many of these fungal infections are rare; however, they can be detrimental to the immunocompromised. Some patient populations that frequently use itraconazole prophylaxis are patients with HIV, those receiving chemotherapy, or people who have had an organ transplant. This activity reviews the indications, mechanism of action, adverse event profile, and ... What Is Itraconazole and How Does It Work? Itraconazole is a prescription medication used to treat fungal infections of the lungs, mouth or throat, tonenails or fingernails. Itraconazole is available under the following different brand names: Sporanox, Onmel, Tosura. Itraconazole is used in the treatment of fungal infections, severe fungal infections and dandruff. It is used to treat fungal infections of the mouth or vagina (thrush), skin and other parts of the body such as finger and toenails. Itraconazole is an antifungal medication. Itraconazole is an antifungal medicine used to treat fungal infections of the mouth, throat, toenails, fingernails or lungs. A fungal infection is a disease in which a fungus attacks the tissue and causes infection. Fungal infections may be contagious (spread from one person to another).