Insulin Resistance: Causes and Solutions In recent years, insulin resistance has garnered significant attention in the medical community due to its critical role in the pathogenesis of type 2 diabetes and other metabolic disorders. As a condition characterized by the body's diminished ability to respond to insulin, insulin resistance represents a pivotal concern for both healthcare professionals and individuals striving for optimal health. This article delves into the causes, symptoms ... INSULIN RESISTANCE definition: 1. a condition in which the body's muscles and other tissues do not accept the insulin that they…. Learn more. Insulin resistance is a condition that raises your risk for type 2 diabetes. Learn about signs and how to reduce the risk. Insulin resistance occurs when the body's cells become less responsive to the hormone insulin, which is produced by the pancreas. Insulin plays a vital role in regulating blood sugar levels by facilitating the uptake of glucose into cells for energy.