Aromatic formylation, also known as the Gattermann-Koch reaction , is a classic organic synthesis reaction involving converting an aromatic compound to an aldehyde by introducing a formyl (-CHO) group onto the ring. The reaction is named after its discoverers, the German chemists Ludwig Gattermann and Julius Arnold Koch . Learn about Gattermann - Koch formylation, used in the synthesis of benzofuran-derived natural products and other compounds used as fluorescent probes or anti-tumor agents. Learn how benzene reacts with CO and HCl to form benzaldehyde in the presence of Lewis catalysts and a co-catalyst. Find out the reaction mechanism, applications, and limitations of this electrophilic substitution process. Learn about the Gattermann Koch Reaction , its mechanism, required conditions, suitable substrates, and real world applications. A complete guide for chemistry students and aspirants.
