The cytoplasm is all the material within a eukaryotic or prokaryotic cell, enclosed by the cell membrane, including the organelles [1] and excluding the nucleus in eukaryotic cells. The cytoplasm is a fluid-like substance that fills up the cells. Cellular organelles and structures are suspended in the cytoplasm . The cytoplasm is a highly viscous substance within the cell membrane & composed of water, proteins, lipids, nucleic acids, inorganic salts, polysaccharides. CYTOPLASM definition: 1. the substance inside a cell that surrounds the cell's nucleus 2. the substance inside a cell…. Learn more.