Catastrophe definition : a sudden and widespread disaster.. See examples of CATASTROPHE used in a sentence. The meaning of CATASTROPHE is a momentous tragic event ranging from extreme misfortune to utter overthrow or ruin. How to use catastrophe in a sentence. Did you know? Definition of catastrophe noun in Oxford Advanced Learner's Dictionary. Meaning , pronunciation, picture, example sentences, grammar, usage notes, synonyms and more. Definition of CATASTROPHE in the Definitions.net dictionary. Meaning of CATASTROPHE . What does CATASTROPHE mean ? Information and translations of CATASTROPHE in the most comprehensive dictionary definitions resource on the web.