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Buerger disease decreases blood flow to the hands and feet. As the disease gets worse, the skin and tissue in the affected areas do not get enough blood. This can cause painful open sores that do not heal. Thromboangiitis obliterans, also known as Buerger disease, is a smoking-related inflammation and clotting of blood vessels in the hands and feet. Learn about its signs, symptoms, diagnosis, prevention and treatment options. Buerger's disease is a smoking-related vasculitis of small and medium-sized arteries, causing limb ischaemia and tissue loss. Learn about its symptoms, diagnosis, treatment, prevention and prognosis from BMJ Best Practice. Buerger’s disease is a disease that can cause inflammation of blood vessels in the hands and feet. Using tobacco increases your risk of developing it and the likelihood of serious complications.