Blood type Blood type (or blood group) is determined, in part, by the ABO blood group antigens present on red blood cells. A blood type (also known as a blood group) is a classification of blood based on the presence and absence of antibodies and inherited antigenic substances on the surface of red blood cells (RBCs). Blood grouping is a systematic classification of blood based on the presence or absence of specific antigens on the surface of red blood cells. This classification is fundamental to modern medicine, particularly in transfusion therapy, where matching compatible blood types between donors and recipients is crucial to prevent potentially life-threatening reactions. The discovery of blood groups revolutionized medical practice by making blood transfusions safer and more predictable. Blood Groups Definition The genetically determined system by which blood can be classified into different groups according to the presence or absence of agglutinogen, i.e., antigens on the surface of RBCs and the antibody in the blood plasma, is called the blood grouping system. Blood groups have been a topic of interest and research for many years. With advances in medical science, the knowledge and understanding of blood groups have also increased. This article will discuss everything you need to know about blood groups, including what they are, how they are determined, their importance, and their impact on medical procedures and transfusions.