We are having our biggest sale yet!! Up to 70% off on heycuties.com! Definition of bestie noun in Oxford Advanced Learner's Dictionary. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more. Get a quick, free translation! BESTIE definition: 1. someone's best friend: 2. someone's best friend: . Learn more. In the annals of relationship dynamics, the term "bestie" has evolved over the decades, but its roots are deeply entrenched in human behavior and the need for social connection. The word, a colloquial abbreviation of 'best friend', transcends mere friendly relations and delves into the deeper realms of emotional and psychological bonding.