Antimicrobial Resistance (AMR) occurs when bacteria, viruses, fungi and parasites change over time and no longer respond to medicines making infections harder to treat and increasing the risk of disease spread, severe illness and death. Antimicrobial Resistance Antimicrobial resistance happens when microbes (like bacteria and fungi) are able to outsmart medications providers use to treat them. This can happen naturally or when certain medications are used a lot — germs can develop changes (mutations) that allow them to survive common drugs. It’s hard to treat infections caused by antimicrobial-resistant germs. A comprehensive review of antimicrobial resistance (AMR), a global health threat driven by antibiotic misuse and overuse. Learn about the history, mechanisms, impacts, challenges, and solutions of AMR, and how artificial intelligence can help combat it. AR happens when germs like bacteria and fungi develop the ability to defeat the drugs designed to kill them. That means the germs are not killed and continue to grow. Resistant infections can be difficult, and sometimes impossible, to treat.