Adapalene + Clindamycin is a combination medicine. It is used to treat acne. Both. the medicines work by inhibiting the growth of bacteria causing pimples, reducing swelling and inhibiting the formation of blemishes due to the accumulation of oil and dirt. Adapalene + clindamycin is a combination of two medicines, namely: Adapalene (human-made vitamin A) and Clindamycin (antibiotic). Adapalene + Clindamycin is a combination of two medicines: Adapalene and Clindamycin , which treats pimples (acne). Adapalene is a form of vitamin A which prevents accumulation of the sebum (skin’s natural oil), unblocks the pores and allows natural exfoliation of the outer layers of skin. Adaple-C Gel is a combination of two medicines: Adapalene and Clindamycin , which treat pimples (acne). Adapalene is a form of vitamin A that prevents the accumulation of sebum (skin’s natural oil), unblocks the pores, and allows natural exfoliation of the outer layers of skin. Clindamycin is an antibiotic that works by penetrating the skin and killing acne-causing bacteria.